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Another key player is the p53 gene, which is now recognized as a cancer suppressor and important regulator of microenvironment in the stem cell niche [ 13 ]
For example, the reduction of SCFAs (such as butyrate) caused by gut microbiota dysbiosis weakens their inhibitory effect on HDACs, thereby enhancing the pro-inflammatory phenotype of Kupffer cells
Y., et al
In experimental models, it may be included as a reference peptide when studying stress-response pathways, circadian-adjacent biology, and downstream molecular readouts linked to brainbody communication
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