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The impact of glucagon-like peptide-1 on bone metabolism and its possible mechanisms

dose escalation may be delayed if necessary based on tolerability

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Emerging data from meta-analyses, subgroup analyses, and observational studies suggest possible additive benefits of combination therapy

Advances in the understanding of gut hormone physiology particularly their role in appetite regulation, metabolism, and glucose homeostasis - have driven the development of glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) as effective and safe treatments for type 2 diabetes (T2D) and obesity