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This binding enhances the activity of GTPase Drp1, resulting in mitochondrial fusion and fission imbalances, mitochondrial distribution abnormalities, and mitochondrial axonal transport defects

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Nature Reviews Neuroscience , 12(8), 453-466

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Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used remedies, but their interaction with GLP-1 therapy deserves careful consideration