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Our realworld data show that many patients who stop semaglutide or tirzepatide restart the medication or transition to another obesity treatment, which may explain why they regain less weight than patients in randomized trials, said Hamlet Gasoyan, a researcher with Cleveland Clinic's Center for Value-Based Care Research, who also led the study

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When your body is already in appetite suppression mode from semaglutide, consuming additional fats without hunger to guide portion sizes can lead to overconsumption or digestive distress

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