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172,173 For instance, the primary effect of SLC2A9 (rs12498742) explains 2% to 3% of serum uric acid level variance in Europeans, which is substantial for a complex phenotype

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Furthermore, various factors including aging, iatrogenesis, and the environmental factors can lead to basement membrane damage and therefore easier migration of melanocytes and melanin to skin layers and their accumulation within the dermal layer

Alzheimers disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis