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Instead, therapeutic modulation of GSH must be tailored to disease context, reflecting the fundamental GSH paradox: whereas cancer therapy often seeks to deplete elevated GSH to induce oxidative stress and cell death, neurodegenerative and inflammatory diseases may require restoration of GSH homeostasis

These supplements help with digestion, nutrient absorption, and immune defense, especially important for someone with a physically demanding lifestyle and travel-heavy schedule

Nevertheless, other enzymes (peroxidases) including peroxiredoxins and glutathione peroxidases, which use thioredoxins or glutaredoxins as reducing substrates, also contribute to H 2 O 2 removal in plants

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This subcellular localization enables the direct protection of mitochondrial lipids, proteins, and mtDNA from oxidative damage, a critical advantage in diseases like neurodegeneration and metabolic disorders