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Although our knowledge of the mechanisms of activity-dependent structural plasticity of inhibitory synapses is still limited, this study suggests that, like excitatory synapses, inhibitory synaptic plasticity might not only depend on changes in the biophysical properties of the channels, but might also involve a structural reorganization of its inhibitory postsynaptic density, by altering the number of channels and the necessary structural components

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2017;10(462):eaaf8608