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AAV vectors are generally safe at therapeutic doses eight AAV-based gene therapies have been FDA-approved as of 2024 but at high doses, above roughly 10^14 viral genomes per kilogram, the literature documents immune reactions, liver toxicity, and in rare cases, genotoxicity

Kresladi, a lentiviral vector-based gene therapy to treat severe leukocyte adhesion deficiency-I (LAD-I), has already faced delays from the agency as it was initially supposed to find out its fate in March 2024

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T., Herranz, D., Velasco-Miguel, S., Serrano, M

For example, after we have not eaten for several hours, GSH production in many of our cells slows considerably