Currently, there is no cure for PD and additional effective treatments for this devastating disease are urgently needed
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FMT from low-histidine donors and mono-colonization of germ-free fruit flies with Enterobacter cloacae increase triglyceride accumulation and decrease histidine content, revealing interactions between microbiota, histidine catabolism, and NAFLD
Patients should be monitored for potential biphasic reactions following initial symptom resolution
The X-box-binding protein-1 (XBP1), spliced and activated by IRE1, is downregulated in glomerular mesangial cells, weakening the inhibitory effect on the phosphatase and tensin homolog (PTEN)/Akt pathway, thereby aggravating kidney damage