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Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and attenuating tumor hypoxia

GHK-Cu is a naturally occurring tripeptide discovered in 1973 that has broad biological activity extending well beyond cosmetic applications, while Matrixyl is a synthetic signal peptide specifically designed to mimic a collagen fragment and trigger new collagen synthesis

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However, their impact on skeletal muscle mitochondrial function, particularly under metabolic stress, remains unclear