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In 2020, the results of a clinical trial were published in the New England Journal of Medicine that demonstrated the effectiveness of semaglutide for weight loss
Studies in mice and humans showed that GLP-1 liraglutide acts directly and indirectly in LDL and VLDL catabolism, increases lipoprotein lipase gene expression responsible for TAG hydrolysis, and reduces apolipoprotein B48, diacylglycerol O -acyltransferase 1, and microsomal transfer protein gene expression, all of which are involved in chylomicron synthesis [77, 78]
Since launching its rolling BLA submission in December under an Accelerated Approval pathway, Sangamo has submitted preclinical and clinical modules, as well as submitted its antibody assay companion diagnostic, designed to screen patients for eligibility with isaralgagene civaparvovec, to the FDAs Center for Devices and Radiological Health (CDRH), seeking Premarket Approval (PMA).
Dtsch rzteblatt News 04.07.2023, abgerufen am 04.07.2023 Calvarysky B et al
