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The clinician group commented that obesity should be recognized as a complex, chronic, progressive, and relapsing condition

That includes starting some patients at a lower dose of a drug and gradually increasing it until they reach a higher target dose

In addition to these findings on atherosclerotic plaque formation, GLP-1R agonists prevented the increase in plasminogen activator inhibitor type-1 (PAI-1) and vascular cell adhesion molecule-1 (VCAM-1) gene expression in response to TNF- or hyperglycemia in HUVEC through PKA pathway [24],[70]

The rising appeal of GLP-1 drugs for cosmetic weight loss has led to a significant increase in off-label prescribing, which can result in unnecessary claims, legal or ethical dilemmas and the risk of poor health outcomes for individuals who may not receive the right support for their condition

Frontiers in Medicine