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Both agents can enhance glucose-dependent insulin secretion, reduce glucagon secretion, and delay gastric emptying [Reference Chiappini, Vickers-Smith, Harris, Papanti Pelletier, Corkery and Guirguis43Reference Knudsen and Lau45]

However, individual responses vary, and any significant mood changes should be taken seriously

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Taking a PDE5 inhibitor with chest pain or blood pressure medication can lead to a dangerous drop in blood pressure

A 2026 real-world cohort found that within-individual changes in BMI tracked with changes in menstrual irregularity 3 : when your weight shifts meaningfully, your cycle often shifts with it