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Elevated estrogen levels can also impair bile acid transporters, contributing to cholestasis and worsening liver function[64,65]

This study demonstrated the potential clinical efficacy of [d-Trp6]-LH-RH in the treatment of prostate carcinoma in man 10

The human evidence is more limited and more mixed

Additionally, disturbances in autophagy-lysosome degradation process, where the assembly of ATPases was interrupted and the lysosome in RPE cells was alkalinized, led to the digestion of ACSL4 protein, and ultimately to ferroptosis (91)

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