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27 Clinicaltrials.gov

So, for those with hypermobility considering these medications, a baseline DEXA scan, adequate vitamin D and calcium intake, and monitoring of bone density over time seem like reasonable precautions if proceeding

What the evidence also shows is that the medication alone is not the whole answer

and (4) LC chelated with metal ions by forming complexes with lysine and methionine amino acids, which are precursors for the first biosynthetic step of LC, while metal ions directly affect LC transfer via inhibition of carnitine acetyltransferase enzymatic activity (mitochondria) or indirectly by mediating organic cation transporter 2 activity (gut absorption) (Tjale et al