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Battaglia M, et al

Thyroid follicular cells themselves can aberrantly express MHC class II and co-stimulatory molecules (B7.1/CD80), enabling them to act as non-professional antigen-presenting cells (APCs) and amplify the autoimmune cascade

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These results revealed that CREB1/CRTC2 is a specific transcriptional activator complex of miR-93 HG

Current therapeutic approaches, such as disease-modifying anti-rheumatic drugs (DMARDs) and biologics, are limited by infection risks, poor tissue specificity, and suboptimal long-term efficacy, underscoring the need for novel therapies