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It works by stimulating the pituitary gland to produce and release endogenous growth hormone (GH), which in turn raises insulin-like growth factor-1 (IGF-1) levels

Several analyses published in recent months document this

Long-term data on durability and safety are still being evaluated

The mechanisms contributing to this combination's efficacy may include central potentiation of hypothalamic interleukin-6 (IL-6) activity enabling post-leptin receptor potentiation of leptin action, as genetic or pharmacological interruption of IL-6 action attenuates the weight loss activity of amylin in mice [16]

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