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It is unclear how long it may take until there are any health benefits of IGF-1 LR3 when used in vivo

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VLDL particles are metabolized into LDL particles, so cutting VLDL synthesis at the source reduces the total LDL burden

For a deep (really deep) dive into the research studies that show the mechanics and efficacy of GLP-1 medications for weight loss, this video from Harvard Medical School gives in depth answers