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IGF-1 LR3 can feel more direct because it acts downstream at IGF-1 receptors, while HGH creates broader endocrine changes upstream

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doi:10.1001/jama.2013.280490

These behavioral benefits are underpinned by its marked ability to induce spinogenesis and promote functional synaptogenesis in hippocampal neurons, highlighting its potential as a robust procognitive and antidementia agent [1]