Functionalized PLGA nanoparticles, modified with ligands or peptides, demonstrated the ability to cross the BBB, enabling their use in neurological disorders like PD 116,117
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Glutamate can be further catabolized through the TCA cycle (via conversion to KG) or serve as a substrate for glutathione synthesis
In light of this, the pathophysiological relevance of the ASPL-VCP interaction warrants further investigation in more physiologically relevant systems, such as patient-derived neurons, animal models, or chronic stress paradigms, which may better recapitulate the characteristic pathological accumulations of ubiquitin and SQSTM1 observed in MSP and related disorders
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