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ICER evaluated them at launch and concluded they exceed $150k/QALY unless prices fall dramatically or only very few patients are treated ( [26] )

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In this review, we examine the impact of supplementing this important urea cycle intermediate on cardiovascular and metabolic health outcomes and identify future directions for investigating its therapeutic impact on cardiometabolic health

High or frequent dosing is the main concern, and people with kidney, liver or other conditions are most at risk