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By binding to ghrelin receptors in the hypothalamus, it mimics its functions, which are primarily reflected in the stimulation of appetite and the secretion of growth hormone

The hosts also dig into how brands are factoring in the rise of GLP-1 drugs when shaping innovation pipelines

(2022) 8:eadc9317

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Indeed, while enhanced GLP-1R signaling outside of the islet may mediate, at least in part, the in vivo effects of GLP-1R agonists on enhanced islet function, studies performed in isolated islets, in the absence of peripheral GLP-1R signaling, confirm the propensity for GLP-1R agonists to induce direct intra-islet effects ( Figure 4 )