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Endothelial dysfunction promotes pro-inflammatory and oxidative stress pathways through the generation of reactive oxygen species (ROS) in endothelial mitochondria

Alternative approaches include supplementing with precursor nutrients such as N-acetylcysteine (NAC), which the body can use to synthesise glutathione naturally, though NAC is also not recommended for NAFLD in NICE guidance and should not be self-prescribed for liver disease

BPC-157 is not recommended for anyone who is pregnant, may become pregnant, or nursing, nor is it endorsed to be used by children

Whether those benefits are sustained long-term, whether the safety profile holds up across larger and more diverse populations, and whether the drug-vs-biologic classification battle shapes patient access these are the questions that 2026's remaining TRIUMPH readouts will begin to answer