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Vourloumis group explored a large series of weaker zinc binding groups as potential alternatives to, e.g., the zinc binding amide function found in the 3,4-diaminobenzoic acid derivatives 47 and 48 ( Conclusion A series linear Ang IV analogues demonstrating improved metabolic stability and very high affinity to IRAP have been reported, e.g., the potent hexapeptides 11 (AL-11) and 12 (IVDE77) with Ki values of 7.6 and 1.7 nM, respectively, data to be compared with the Ki value of Ang IV of 62 nM in the same binding assay

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Insulin-like growth factor-1 signaling is modified during chondrocyte differentiation

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These external labs use state of the art instrumentation and validated methods to provide accurate compound characterization