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In OASIS-4, gastrointestinal side effects were reported in about 74% of participants taking oral semaglutide, compared with 42% in the placebo group

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Preclinical studies provide robust mechanistic support, particularly through serotonergic modulation, BDNF/TrkB signaling, and hippocampal neurogenesis, although translational dose equivalence remains uncertain

No differences in Gclc mRNA were observed in surrounding tissues (Fig