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Whatever it is, this will help to increase feel-good hormones and endorphins such as serotonin and dopamine, and decrease cortisol levels, improving mood

Journal of the American Board of Family Medicine, 19(6), 542-547

This is an extreme model: a full transection of the quadriceps muscle in a rat

Gentle swirling is acceptable, but shaking can denature the peptide and reduce potency