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Through inhibition of key targets, such as TGF- and P4HA1, GLP-1RAs exert antifibrotic and immunomodulatory effects, demonstrating protective potential in multiple organs, including the heart, kidneys, liver and lungs (160)

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In research models, its studied for its interaction with GHRH receptors on the pituitary gland, where it prompts the pituitary to release endogenous growth hormone through the bodys own regulatory pathway rather than introducing growth hormone directly, as some other compounds in this research category do

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Challenges in Developing Multi-Receptor Agonists In the era of multi-receptor agonists and increasingly personalised medicine, striking the balance between the relative potency of agonists across various receptors poses a challenge