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Additionally, cytokine-targeting therapies, including tocilizumab (an anti-IL-6 receptor inhibitor) and anakinra (an anti-IL-1 receptor antagonist), have been shown to be effective in treating immune-mediated epileptic syndromes, such as new-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES) [358, 359]