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One of the reasons many calorie restriction diets are so ineffective in producing weight loss for some is because the human body naturally wants to adjust to the reduced calories by also reducing metabolism

PMID 24348349

These effects are generally dose-dependent, typically mild to moderate in severity, and most pronounced during dose initiation or escalation

Rather, it is to engineer a pharmacologic signal in which glucagons catabolic properties are preserved while its hyperglycemic liability is buffered by incretin-mediated glucose control

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