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The biological effects downstream of cAMP elevation have been previously demonstrated to be predominately mediated by cAMP-dependent protein kinase (PKA), which phosphorylates cAMP-response element (CRE) binding protein (CREB) (21)

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doi: 10.1016/j.critrevonc.2007.06.005 72 BhoopathiPChettyCGujratiMDinhDHRaoJSLakkaS

Semaglutide mimics GLP-1