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Observational studies have associated alterations in cortisol patterns, such as flattened diurnal curves or elevated evening levels, with obesity, metabolic syndrome, and cardiovascular risk, though these findings do not establish causality

Vitamins and type 2 diabetes mellitus

GLP-1Ra was linked to a decrease in fracture risk (overall response 0.71, 95% CI 0.560.91) compared to placebo or other anti-diabetic medications [78]

Innovations introduced longer-acting formulations: semaglutide (novel peptide with fatty acid modifications) enabled once-weekly dosing and was first approved as Ozempic (T2D, 2017) and then as Wegovy (obesity, 2021)

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