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Patients who use tobacco should be counseled on smoking cessation, as it has been identified as a risk factor for widespread CLE, it can increase disease severity, and it can decrease the efficacy of antimalarial therapy

[34] [108] [109] [110] [3] GLP-1 receptor agonists like semaglutide may indirectly positively influence testosterone levels via weight loss in obese men, but this is not a direct interaction and does not indicate adverse effects

Injectable semaglutide affects the gut primarily through systemic GLP-1 receptor activation, while sublingual semaglutide and oral semaglutide drops also involve direct contact with the GI mucosa