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However, in comparison to 7% of cutaneous melanoma, amelanotic melanoma contributed to 37% (14/38) in one of the series [17]

market projected to grow from $18.2B in 2025 to $72.5B by 2035 ~14.8% CAGR driven by gene editing, rare diseases, and personalized medicine At the same time, the pipeline is becoming more complex: oncology represents over 50% of CGT trials increasing focus on small, targeted patient populations These therapies introduce new operational demands: individualized treatments complex manufacturing and logistics need for more integrated trial models The implication is clear: cell and gene therapies are not scaling within traditional trial frameworks, they are forcing the industry to redesign them

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