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Pregnant women with elevated homocysteine levels have an increased risk of gestational diabetes, miscarriage, preeclampsia, and premature delivery.29 Additionally, infants born to women with folate and vitamin B12 deficiencies and elevated blood homocysteine levels were found to have an increased risk of developing insulin resistance by age 6, compared with women with values in the normal range.2 Daily supplementation with 5 to 10 mg of folic acid for up to 12 weeks significantly lowered plasma homocysteine levels among 426 patients with type 2 diabetes

10.1002/bab.1853 75 IsabelC.-H.Mara ngelesM.LuisG.SoniaR

De Francesco was supported by a fellowship from the Associazione Italiana per la Ricerca sul Cancro (AIRC) co-funded by the European Union

Several later papers involved authors with commercial development interests

J Allergy Clin Immunol 2015;135:104452.e5