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The compressed IVD showed signs of degeneration and inflammation, including the appearance of MMP-13, TNF-alpha, and IL-1 beta, as well as the expression of pain-related molecular markers, such as substance P

10.1212/01.WNL.0000154641.08211.B7 33 MuratoreC

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[55] In conditions like obesity, compromised gut barriers can allow bacterial lipopolysaccharides (LPS, or endotoxins) to enter the bloodstream, triggering severe immune responses via TLR4 receptors

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