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Next, frozen extract and one frozen blood aliquot from each subject were sent on dry ice to Ms-Omics facility for analysis

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GST catalyzes the GSH-mediated hydrolysis of sulfonamide bonds, releasing GST competitive inhibitors such as benzylsulfonyl-GSH or S -benzyl-GSH (Koeplinger et al., 1999

From randomization (week 20) to Week 68, treatment with WEGOVY injection resulted in a statistically significant reduction in body weight compared with placebo (Table 9)