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Finally, among GLP-1 RA, the Effect of Efpeglenatide on Cardiovascular Outcomes (AMPLITUDE-O) trial demonstrated a beneficial effect of weekly efpeglenatide on MACE and on a composite kidney outcome (decrease in kidney function or severe albuminuria) [247]

Depression and Anxiety: Some preliminary studies have shown that GLP-1 receptor agonists might have antidepressant and anxiolytic effects by influencing brain areas involved in mood regulation

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