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IGF-1 LR3 is used when researchers need to study IGF1R activation directly, bypassing the GH-IGF-1 axis entirely

Mouse redox histology using genetically encoded probes

Therefore, they speculated that caffeic acid probably acts as a major player in the preventive effect of chlorogenic acid against oxidative damage in ischemiareperfusion intestinal tissue [170]

It extends its effect by maintaining GH secretion over longer periods, including preserving the natural episodic or pulsatile pattern of GH release rather than creating flat, constant levels