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The adverse effect spectrum of JAK inhibitors directly results from their mechanism of action in obstructing the JAKSTAT signaling pathway

Oxidative stress may contribute to processes involved in cardiovascular disease, including endothelial dysfunction, LDL oxidation, inflammation, mitochondrial injury, and plaque formation

Epinephrine exerts -adrenergic vasoconstrictive effects , increasing aortic diastolic pressure and coronary perfusion during cardiopulmonary resuscitation, and -adrenergic effects , increasing heart rate and myocardial contractility to facilitate return of spontaneous circulation (ROSC)

38 Although numerous questions remain about the mechanism by which GSH may ameliorate PD symptoms, this study demonstrates that a single dose of (in)GSH does, in fact, reach the target tissue

DOI: Hassan DHM, Al-joranii SM