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ROS generation leads to oxidation of the ASK1 inhibitor thioredoxin, separating and activating ASK1 from the inactive ASK1thioredoxin complex

563 Monitoring and considerations include dose titration, initiating medications at low doses and gradually increasing to the maximum tolerated dose while monitoring efficacy and adverse effects

According to the CDC, age-adjusted death rates were 35 times higher in 2021 than in 2018 (Putka 2023

Aksenov MY, Markesbery WR