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It occurs due to inflammation and irritation at the site of injection

Lancet Neurol 6:10451053 Drachman DB, Frank K, Dykes-hoberg M et al (2002) Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS

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Specifically, when injected orthotopically, 67NR cells do not metastasize, 4T07 tumors seed micrometastases only in the lung, whereas 4T1 are overtly metastatic TNBC cells (Avgustinova et al, 2016)