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KPV interrupts this process by stabilizing IkB-alpha and blocking the nuclear translocation of the p65/RelA NF-kB subunit through competitive interference with the importin-alpha3 transport mechanism

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Epidemiology of breast cancer: statistics and prevalence Breast cancer, as of 2020, was ranked number one in the number of new cases with 11.8% of incident rates, and number 4 in the cause of cancer-related deaths, with Asia having an incidence rate of 45.4%, 23.5% in Europe, 12.5% in North America, 9.3% in Latin America and the Caribbean, and 8.3% in Africa ( Table 1 ), reflecting differences in risk factors, healthcare access, screening practices, and socioeconomic development

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