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The SURPASS-3 MRI substudy added another layer, showing tirzepatide actually reduced muscle fat infiltration across all doses, indicating improved muscle quality even as total muscle volume decreased

The prescribing information for FDA-approved semaglutide injection contains information about overdoses that have been reported with other GLP-1 receptor agonists

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Indeed, activation of GLP-1Rs expressed on presynaptic terminals in the hippocampus has been shown to enhance depolarization-evoked GABA release 57

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