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Kasapolu and Seli, 2020)

Standardized techniques for collecting and processing samples from feces, plasma, and peripheral tissue biopsies are required to assure repeatability

TF is mainly present in the plasma, which binds to the cell surface transferrin receptor 1 (TfR1) to supply the iron needed by most tissues of the body (15)

Consistent with an induction of oxidative stress condition, metformin increased mRNA levels of the master redox transcription factor Nrf-2 (nuclear factor erythroid-derived 2-like), as well as transsulfuration enzymes cystathionine beta-synthase and cystathionase and GSH synthesis enzymes -glutamylcysteine synthetase and glutathione synthetase

Oncotarget 8 (15), 2531025322