The molecular pathways associated with the altered proteome include plasma lipoprotein assembly, chylomicron assembly, chylomicron remodeling, VLDL (Very low-density lipoprotein) clearance, plasma lipoprotein clearance, and chylomicron clearance
An increase in oxidative stress and cell damage causes an increased usage of glutathione and decreased levels
54 These species-specific patterns reflect underlying physiological characteristics, including the cell envelope, efflux systems, and thiol metabolism
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In human ocular explant models, Erastin triggers adjacent PR damage and disruption of the BRB, which is not observed in rodent models ( In recent years, nanocarriers, hydrogels, and targeted carriers for the treatment of ocular diseases by targeting ferroptosis have emerged accordingly