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The number of studies available in humans was limited, and the results were mixed
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Results: The clinical background of all patients was as follows: mean age 70.412.3 years, male/female 343/220, etiology alcohol/HBV/HCV/NASH 231/53/123/105, total bilirubin 1.82.5 mg/dL, albumin (Alb) 3.230.73 g/dL, prothrombin time (PT) 70.920.1, serum zinc 56
The MDPI review reports that short sleep duration is associated with increased ghrelin and decreased leptin, hormones involved in hunger and satiety. Together, these findings show that sleep quality and duration influence how the body adapts to a calorie deficit