In vivo , intraperitoneal administration of the NRF2 activator RTA-408 significantly upregulated NRF2 expression in neurons of SOD1 G93A transgenic mice, which consequently elevated the expression of GSH, SLC7A11, and GPX4, reduced MDA and ROS levels, suppressed neuronal ferroptosis, lipid peroxidation, and mitochondrial injury, and ameliorated weight loss and motor dysfunction in mice (Yang et al., 2023)
The liposomal delivery system is the real differentiator here
Scand J Med Sci Sports
Role in Growth and Development It plays a vital role in growth and development, as it promotes: Cell proliferation 19 Organ growth 20 Tissue differentiation 19 Bone growth and remodelling 21 Brain development 22 Neuroplasticity 22 It is particularly important during childhood and adolescence, when growth and development occur most rapidly
FOXO4-DRI has a rapidly expanding and high-impact published research base, with studies published across Nature, Nature Communications, Communications Biology, Aging, Frontiers in Bioengineering and Biotechnology, and PMC since its foundational description in 2017
