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These microbiota-derived agents can inhibit Gram-negative pathogens through diverse mechanisms, such as direct bactericidal activity, modulation of host immune responses, and promotion of colonization resistance

Diabetes Care 33 , 24772483 (2010)

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In addition, the microbiota plays a role in maintaining oral tolerance, controlling intestinal and bloodbrain barrier permeability, and modulating the hypothalamicpituitaryadrenal axis, which in turn influences tryptophan metabolism