10.1067/mpd.2001.114480 J
Moore does: the body is an integrated system, and symptoms rarely sit in isolation
136560-76-4 Appearance Liquid Molecular Weight 395.62 Formula C 24 H 45 NO 3 Color Colorless to light yellow Shipping Room temperature in continental US
Given that the extracellular GSH/GSSG and cysteine/CySS redox pools are under tight regulation during physiologic health (156, 157), these observations reflect a global disturbance in both thiol availability and thiol redox signaling in individuals with severe asthma that likely has important clinical and therapeutic implications
Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways