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Research from both epidemiological studies and laboratory experiments supports this

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and folate as Quatrefolic, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF

The C9orf72 DPRs also interact with mitochondrial proteins, resulting in mitochondrial dysfunction, inflammation, and neurotoxicity (Gendron and Petrucelli, 2018)